Nikola pavletich biography

Nikola Pavletich.
Pavletich uses X-ray crystallography to map the three-dimensional shape of the molecular components that control cell growth.
Nikola Panayot Pavletich is the former chair of structural biology at Memorial Sloan Kettering Cancer Center.

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Nikola P. Pavletich

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Warren C, Pavletich NP. (2022) Structure of the human ATM kinase and mechanism of Nbs1 binding. Elife. 11Yang H, Pavletich NP. (2021) Insights into homology search from cryo-EM structures of RecA-DNA recombination intermediates. Current Opinion in Genetics & Development. 71: 188-194Wang S, Wang R, Peralta C, et al. (2021) Structure of the FA core ubiquitin ligase closing the ID clamp on DNA. Nature Structural & Molecular BiologyYang H, Zhou C, Dhar A, et al. (2020) Mechanism of strand exchange from RecA-DNA synaptic and D-loop structures. NatureWang R, Wang S, Dhar A, et al. (2020) DNA clamp function of the monoubiquitinated Fanconi anaemia ID complex. Nature. 580: 278-282Wojnarowicz PM, Lima E Silva R, Ohnaka M, et al. (2019) A Small-Molecule Pan-Id Antagonist Inhibits Pathologic Ocular Neovascularization. Cell Reports. 29: 62-75.e7Yang H,

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Structural Biology

Edited by : Neeraja Sankaran

Y. Cho, S. Gorina, P.D. Jeffrey, N.P. Pavletich, "Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations," Science, 265:346-55, 1994. (Cited in more than 140 publications through November 1995)

Comments by Nikola Pavletich, Memorial Sloan-Kettering Cancer Center, New York City

"One of the goals in cancer biology has been to find a unifying theme underlying the cause of cancer, and the p53 tumor suppressor is the closest we have come to that," declares Nikola Pavletich, an assistant member in the cellular biochemistry and biophysics program at Memorial Sloan-Kettering Cancer Center in New York.

"Because it is the most frequently mutated gene to be identified in triggering many different human cancers, p53 has been the focus of intense research. This paper is the first description of the three-dimensional atomic structure of p53 bound to a DNA molecule," he adds, proposing this as the main ...

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Nikola Pavletich

Naseer Rajput

Nikola Panayot Pavletich is the former chair of structural biology at Memorial Sloan Kettering Cancer Center.^[1]

Education

Pavletich received his BS in chemistry from Caltech in 1988 and his PhD in molecular biology and genetics from Johns Hopkins University School of Medicine in 1991.^[2] He did a postdoc at MIT with Carl Pabo.

Career

He joined the faculty at Sloan Kettering in 1993 and was named chair of the Structural Biology Program in 2003.^[3] He has been an HHMI investigator since 1997.

His laboratory researches malignant cell growth and DNA damage contributing to the development of cancer. DNA damage repair is a significant factor in whether a cell will become cancerous after genetic insult. Some of his major focuses have been the mTOR pathway and BRCA1. His lab uses x-ray crystallography to determine how proteins interact.^[4]^[3]